How Fevers REALLY Work

How Fevers REALLY Work

Watch the new season of MinuteBody – and get access to both CuriosityStream and Nebula – at
Fevers are one of our best weapons against infections, but they don’t work like you might think.

We’d like to give a big thank you to Sharon Evans from the Roswell Park Comprehensive Cancer Center for sharing her expertise for this video!

LEARN MORE
**************
To learn more about this topic, start your googling with these keywords:
Fever: a rise in body temperature, usually caused by infection
Heat shock proteins (HSP): a family of proteins that are produced by cells in response to exposure to stressful conditions
Neutrophils: white blood cells that play an important role in inflammation and are early responders to pathogens.
T cells: major components of the adaptive immune system whose roles include regulating the immune response to pathogens.

SUPPORT MINUTEEARTH
**************************
If you like what we do, you can help us!:
– Become our patron:
– Share this video with your friends and family
– Leave us a comment (we read them!)

CREDITS
*********
Kate Yoshida | Script Writer, Narrator and Director
Arcadi Garcia i Rius (@garirius) | Illustration, Video Editing and Animation
Nathaniel Schroeder | Music

MinuteEarth is produced by Neptune Studios LLC

OUR STAFF
************
Sarah Berman • Arcadi Garcia i Rius
David Goldenberg • Julián Gustavo Gómez
Melissa Hayes • Alex Reich • Henry Reich • Peter Reich
Ever Salazar • Leonardo Souza • Kate Yoshida

OUR LINKS
************
Youtube |
TikTok |
Twitter |
Instagram |
Facebook |

Website |
Apple Podcasts|

REFERENCES
**************
Appenheimer, M.M. & Evans, S.S. (2018) Temperature and adaptive immunity. Handbook of Clinical Neurology 156: 397–415.

Casadevall, A. (2016) Thermal Restriction as an Antimicrobial Function of Fever. PLoS Pathog 12(5): e1005577.

ChangDong L. et al. (2019). Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity 50(1):137-151.

Evans, S.S. et al. (2015) Fever and the thermal regulation of immunity: the immune system feels the heat. Nature Reviews Immunology 15(6): 335+.

Hasday, J.D., Thompson, C., Singh, I.S. (2014) Fever, immunity, and molecular adaptations. Comprehensive Physiology 4:109–48.

Hasday, J.D. & Singh, I.S. (2000) Fever and the heat shock response: distinct, partially overlapping processes. Cell Stress Chaperones 5:471–480.

Javid, B., MacAry, P.A. & Lehner, P.J. (2007) Structure and function: heat shock proteins and adaptive immunity. Journal of Immunology 179:2035–2040.

Mackowiak, P. A.: Direct effects of hyperthermia on pathogenic microorganisms: teleological implications with regard to fever. Reviews of Infectious Diseases 1981, 3: 508–518.

%d bloggers like this: