6 Reasons We Have to Say a Study Was “In Mice”
A lot of our videos include the disclaimer “Mice aren’t people.” But why do we keep saying this, and if rodent studies aren’t effective, why do we keep using them?
Hosted by: Stefan Chin
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Sources:
Intro:
https://www.genome.gov/10005834/background-on-mouse-as-a-model-organism
Alzheimer’s disease:
https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease
https://www.nature.com/articles/d41586-018-05722-9
https://www.biospace.com/article/a-look-at-biogen-s-big-bet-on-the-holy-grail-of-science-and-mdash-alzheimer-s-/
http://investors.biogen.com/news-releases/news-release-details/biogen-and-eisai-discontinue-phase-3-engage-and-emerge-trials
https://www.nature.com/articles/s41586-019-1506-7
Multiple sclerosis:
https://medlineplus.gov/multiplesclerosis.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154595/
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(87)92863-7/fulltext
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586507/
https://www.degruyter.com/view/j/revneuro.2019.30.issue-1/revneuro-2018-0002/revneuro-2018-0002.xml
Hepatitis B:
https://www.cdc.gov/hepatitis/hbv/index.htm
https://www.nap.edu/catalog/4887/review-of-the-fialuridine-fiau-clinical-trials
http://discovermagazine.com/1994/mar/thecurethatkille345
https://www.ncbi.nlm.nih.gov/pubmed/16595656
http://perspectivesinmedicine.cshlp.org/content/5/12/a021451.full
Tuberculosis:
https://www.cdc.gov/tb/publications/faqs/qa_introduction.htm
https://medlineplus.gov/tuberculosis.html
https://www.ncbi.nlm.nih.gov/pubmed/11288517
https://www.ncbi.nlm.nih.gov/pubmed/20819249
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798013/
https://www.jimmunol.org/content/172/5/2731#sec-6
Saccharin:
https://academic.oup.com/annonc/article/15/10/1460/170200
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009921/
https://www.ncbi.nlm.nih.gov/pubmed/9428778
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591507/
https://www.niehs.nih.gov/news/newsroom/releases/2000/may15/index.cfm
Microbiome:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991899/
https://www.nature.com/articles/s41598-018-24342-x#Sec8
https://www.health.harvard.edu/blog/stool-transplants-are-now-standard-of-care-for-recurrent-c-difficile-infections-2019050916576
https://dmm.biologists.org/content/8/1/1#sec-16
https://www.the-scientist.com/news-opinion/mouse-genetics-shape-the-gut-microbiome-more-than-their-environment-66238
https://www.eurekalert.org/pub_releases/2019-08/niod-mc072919.php
Closing:
https://www.nabr.org/animal-research-into-the-worlds-five-deadliest-diseases/
https://commons.wikimedia.org/wiki/File:Neuron.svg
https://commons.wikimedia.org/wiki/File:1FG9_IFNG_IFNG.png#/media/File:1FG9_IFNG_IFNG.png
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